DNA and RNA

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Tero
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Re: DNA and RNA

Post by Tero » Mon Dec 28, 2020 8:34 pm

I used to make nucleosides, the pieces without the phosphate part. I had never seen that, though we changed every part of the sugar and heterocycle to see what the effect was. I collected a report of nucleosides that are substrates for kinases for the boss. Not every nucleoside you can imagine is entered into the natural system of pathways. I correctly predicted that we should make the cytidine analog of things we made. Only the sugar (ribose) parts was changed. Our competition already made one:
https://en.wikipedia.org/wiki/Gemcitabine
it became a cancer drug.

I used to go to conferences where both nucleosides and nucleotides were discussed. Man made nucleotides like the psudouridine were incorporated into DNA bits they made. The trouble back then, 1980-1990, was that injectable drugs were not in favor. So they got nothing past animal studies. There was a big effort to make so called "antisense nucleotides."

Now that we are addressing viral diseases and cancer, it is worth noting that proteins are routinely given by injection, like humira. So there is no longer a hurdle to people wearing some device that slowly feeds the injectable drug into the body.

The future of drugs is in these, and it will be costly. Biochemicals such as these are a great effort to make, compared to our old time "pills."
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NineBerry
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Re: DNA and RNA

Post by NineBerry » Mon Dec 28, 2020 8:35 pm

Everything gets cheaper once you start producing more of them. Think about how cheap smartphones are today.

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Tero
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Re: DNA and RNA

Post by Tero » Mon Dec 28, 2020 8:47 pm

NineBerry wrote:
Mon Dec 28, 2020 8:35 pm
Everything gets cheaper once you start producing more of them. Think about how cheap smartphones are today.
The cheapness in these is labeled "biosimilar,"

https://www.tevabiosimilars.com/?utm_so ... lsrc=aw.ds

Once the patent runs off in humira, these biosimilars will enter the market. They will differ from the innovator drug slightly, just by the technology used to make them.

In the case of RNA or DNA there will also be "trade secrets" that are not patented. You only need to claim the RNA or DNA part with its modified DNA bits to get the patent. You do not need to disclose additives that make your drug stable.

Or you list about 50 additives in your patent claim and say that they all work. You don't say which one is in your drug. You give the FDA the recipe but they do not publish it.

These RNA and DNA wizzards were thought of as dreamers in the 90s because "how would you get it in the cell?"
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If you don't eat your meat, you can't have any pudding!
How can you have any pudding if you don't eat your meat?
You! Yes! You behind the bike sheds! Stand still, laddie!

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Tero
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Re: DNA and RNA

Post by Tero » Mon Dec 28, 2020 9:35 pm

The uridine analog notated with psi is a natural nucleoside and has certain properties:
https://en.wikipedia.org/wiki/Pseudouridine
coronavirus worldometer https://www.worldometers.info/coronavirus/#countries
If you don't eat your meat, you can't have any pudding!
How can you have any pudding if you don't eat your meat?
You! Yes! You behind the bike sheds! Stand still, laddie!

Dominus vo-bisque'em Et cum spear a tu-tu, oh!

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Tero
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Re: DNA and RNA

Post by Tero » Tue Jan 12, 2021 4:15 pm

coronavirus worldometer https://www.worldometers.info/coronavirus/#countries
If you don't eat your meat, you can't have any pudding!
How can you have any pudding if you don't eat your meat?
You! Yes! You behind the bike sheds! Stand still, laddie!

Dominus vo-bisque'em Et cum spear a tu-tu, oh!

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