Drug manufacture

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Tero
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Re: Drug manufacture

Post by Tero » Sun Apr 04, 2021 11:57 am

This was almost predictable
https://amp.cnn.com/cnn/2021/04/03/poli ... index.html

In traditional pill manufacture the bulk drug is done in a dedicated line, sonetimes a building of its own. Also the pills in a dedicated line.

You get FDA approval much faster if there is no chance of two products contaminating each other. It could ne as little as airborne dust with powdered drugs.
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Re: Drug manufacture

Post by BarnettNewman » Sun Apr 04, 2021 12:33 pm

Tero wrote:Articles on the opiate crisis neglect to state the role of the DEA
https://www.npr.org/sections/health-sho ... ust-soared
The DEA is partly to blame as they have to approve the yearly amounts manufactured. They could have approved lesser amounts. Too much regulation?
The problem is whole reason for the DEA existing which is the criminalization of addiction, not the treatment of it. The whole approach to illicit drug oversight in the US is fucked up. It’s not about too much or too little regulation. It’s the right kind of regulation and by whom.


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Tero
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Re: Drug manufacture

Post by Tero » Sun Apr 04, 2021 3:31 pm

hhs.jpg
The DEA is a huge part of the tracking of narcotics. And seizing the smuggled lots. Certainly they deal with addiction too. But the health part of addiction is under NIH. Chart of the HHS department above.
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Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late

Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...

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Re: Drug manufacture

Post by Brian Peacock » Mon Apr 05, 2021 10:32 am

Can someone manufacture some drugs for me please?
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Re: Drug manufacture

Post by Cunt » Mon Apr 05, 2021 3:36 pm

I'll see what I can do once I get back home in a couple weeks. Shipping and logistics is going to be someone else's problem though...;)
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Re: Drug manufacture

Post by Brian Peacock » Mon Apr 05, 2021 6:08 pm

:)
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Clinton Huxley » 21 Jun 2012 » 14:10:36 GMT
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Re: Drug manufacture

Post by JimC » Mon Apr 05, 2021 8:49 pm

Brian Peacock wrote:
Mon Apr 05, 2021 10:32 am
Can someone manufacture some drugs for me please?
In Oz, the gin distilleries are managing to keep up with my demand...
Nurse, where the fuck's my cardigan?
And my gin!

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Re: Drug manufacture

Post by Tero » Wed Jun 09, 2021 11:10 am

I put this in the DNA thread already. making a vaccine is explained at 20 minutes/24min and on. Note: this was 2019---even that company has refined it now.


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Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late

Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...

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Re: Drug manufacture

Post by Tero » Wed Jun 09, 2021 11:16 am

steps...plasmid is the tool making the RNA, replication is from a DNA template inserted into it
mRNA manufacture.jpg
mRNA manufacture.jpg (22.73 KiB) Viewed 5768 times
Company website
https://www.trilinkbiotech.com/custom-mrna-synthesis

press release
https://www.prnewswire.com/news-release ... 80591.html
Last edited by Tero on Wed Jun 09, 2021 11:28 am, edited 1 time in total.
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Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late

Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...

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Tero
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Re: Drug manufacture

Post by Tero » Wed Jun 09, 2021 11:25 am

The plasmid itself is the high cost piece
https://www.trilinkbiotech.com/plasmid

site will not allow cut and paste, but this is the business
https://www.wacker.com/cms/en-us/produc ... ogies.html
https://esapolitics.blogspot.com
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late

Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...

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Tero
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Re: Drug manufacture

Post by Tero » Sat Aug 28, 2021 11:11 am

If one were to try to get away from natural opiates and their derivatives, this one will probably get wide use:
https://en.wikipedia.org/wiki/Tapentadol
Side effects quite similar to tramadol at low dose.

It is made by the German Tramadol maker. The company is most famous for inventing thalidomide.
https://esapolitics.blogspot.com
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late

Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...

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Re: Drug manufacture

Post by rainbow » Sat Aug 28, 2021 9:41 pm

Tero wrote:
Sat Aug 28, 2021 11:11 am
If one were to try to get away from natural opiates and their derivatives, this one will probably get wide use:
https://en.wikipedia.org/wiki/Tapentadol
Side effects quite similar to tramadol at low dose.

It is made by the German Tramadol maker. The company is most famous for inventing thalidomide.
Thalidomide is actually a very safe drug. The problem is that it comes in two optical isomers (as does tramadol), one of which is tetragenic, the other has the good effects and few side effects.

...but give something a bad name.

Heroin too is a safe drug, when taken by mouth. It has very little addition potential unless taken straight into the bloodstream by injection, sniffing, or smoking it. Good for coughs in children.
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Tero
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Re: Drug manufacture

Post by Tero » Mon Sep 27, 2021 12:49 am

Alzheimer drug gets approval. It affects plaques that Alzheimers patients get. But it is not known if the plaque is the direct cause.
https://www.cnn.com/2021/09/26/politics ... index.html
https://esapolitics.blogspot.com
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late

Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...

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Tero
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Re: Drug manufacture

Post by Tero » Mon Jan 10, 2022 6:34 pm

https://esapolitics.blogspot.com
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late

Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...

User avatar
Tero
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Re: Drug manufacture

Post by Tero » Tue Jan 11, 2022 1:59 am

from there:
Johnson & Johnson, the biggest pharmaceutical company in the U.S. based on its market cap, announced in November 2021 it plans to spin off its consumer business into a new publicly-traded company by November 2023. Analysts overwhelmingly say it’s a smart business move, but it could also come with some risks. Watch the video above to learn why Johnson & Johnson is splitting itself up and how investors are reacting.

Johnson & Johnson announced in November that it plans to spin off its consumer business into a new publicly traded company by November 2023.

The news didn’t surprise Wall Street.

“The analyst community has been talking about splitting up J&J for years,” said Jared Holz, health-care equity strategist at Oppenheimer. “The timing situation is critical, just because people have been very curious or intrigued as to why now.”

Johnson & Johnson is the biggest pharmaceutical company in the United States based on market cap. It was ranked 36th on the 2021 Fortune 500 List of the largest U.S. corporations based on total revenue. The company has experienced dividend growth for nearly 60 years and has consistently outperformed the S&P 500 for the past 25 years.

There are other potential headwinds to the split. The company has been dealing with numerous legal challenges over the past several years, many of which are ongoing and could result in as-yet-unknown fines and settlements.
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Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late

Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...

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