Drug manufacture
- Tero
- Just saying
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Re: Drug manufacture
I'm not buying the book!
https://www.npr.org/sections/health-sho ... -you-think
If the FDA suspects a Chinese generic, a more effective way than inspecting plants is to spot check more samples from the US distributor or buy samples from stores.
There appear to be no examples, just "...people on maintenance medications who are taking these drugs day in and day out. Those drugs may have toxic impurities. Those can build up in your liver, you may not know it, or you may be having side effects that you didn't think about before, and then you realize, "Wait a second I was switched to a different generic" or "I was switched from a brand to a generic."
That was all speculation.
If the journalist had money to fly to China, it would have been better spent getting drugs here and sending them to an analytical lab here. Each drug at approved stage has a known impurity profile.
If you take an injectable drug, the risk in generics is greater. Even sealed ampules get bacterial growth.
https://www.npr.org/sections/health-sho ... -you-think
If the FDA suspects a Chinese generic, a more effective way than inspecting plants is to spot check more samples from the US distributor or buy samples from stores.
There appear to be no examples, just "...people on maintenance medications who are taking these drugs day in and day out. Those drugs may have toxic impurities. Those can build up in your liver, you may not know it, or you may be having side effects that you didn't think about before, and then you realize, "Wait a second I was switched to a different generic" or "I was switched from a brand to a generic."
That was all speculation.
If the journalist had money to fly to China, it would have been better spent getting drugs here and sending them to an analytical lab here. Each drug at approved stage has a known impurity profile.
If you take an injectable drug, the risk in generics is greater. Even sealed ampules get bacterial growth.
https://esapolitics.blogspot.com
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late
Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late
Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...
- Tero
- Just saying
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Re: Drug manufacture
One area where generics fail is 12 hour formulas. The tablet does not dissolve at the slow rate. Some drugs also a pressed too hard to pills and take longer to dissolve in your gut. They all would have the right amount of drug per pill.
https://esapolitics.blogspot.com
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late
Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late
Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...
- Tero
- Just saying
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Re: Drug manufacture
Teva makes a good portion of your generics.
https://www.npr.org/2019/05/26/72717991 ... opioid-cas
https://www.npr.org/2019/05/26/72717991 ... opioid-cas
https://esapolitics.blogspot.com
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late
Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late
Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...
- Svartalf
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Re: Drug manufacture
Actually most of mine are Mylan, I get Teva when I go to the Other pharmacy shop.
Embrace the Darkness, it needs a hug
PC stands for "Patronizing Cocksucker" Randy Ping
PC stands for "Patronizing Cocksucker" Randy Ping
- Tero
- Just saying
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Re: Drug manufacture
This is novel: formulate an addiction treatment drug, which they invented, to make it more addictive!
https://www.npr.org/2019/07/11/74085694 ... settlement
The drug is effective if used supervised. Most European heroin addicts are on it. It is of some use in pain relief, and it does not really get you high.
https://en.m.wikipedia.org/wiki/Buprenorphine/naloxone
https://www.npr.org/2019/07/11/74085694 ... settlement
The drug is effective if used supervised. Most European heroin addicts are on it. It is of some use in pain relief, and it does not really get you high.
https://en.m.wikipedia.org/wiki/Buprenorphine/naloxone
https://esapolitics.blogspot.com
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late
Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late
Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...
- Tero
- Just saying
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- Joined: Sun Jul 04, 2010 9:50 pm
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Re: Drug manufacture
Deaths from Suboxone are a very small percentage of opiate deaths.Tero wrote: ↑Fri Jul 12, 2019 12:03 pmThis is novel: formulate an addiction treatment drug, which they invented, to make it more addictive!
https://www.npr.org/2019/07/11/74085694 ... settlement
The drug is effective if used supervised. Most European heroin addicts are on it. It is of some use in pain relief, and it does not really get you high.
https://en.m.wikipedia.org/wiki/Buprenorphine/naloxone
https://esapolitics.blogspot.com
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late
Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late
Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...
- Tero
- Just saying
- Posts: 47366
- Joined: Sun Jul 04, 2010 9:50 pm
- About me: 15-32-25
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Re: Drug manufacture
https://www.newsweek.com/2019/07/19/bot ... 46934.htmlBut for overseas inspections—due to complex logistics of visas and access to the plant—the FDA typically gives weeks or months of advance notice, allowing companies to fabricate critical aspects of their operations. The plants had drafted "internal memorandums and records directing employees to create falsified records in preparation for FDA regulatory inspections," Lal wrote back to senior officials at the FDA's Maryland headquarters.
https://esapolitics.blogspot.com
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late
Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late
Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...
- Tero
- Just saying
- Posts: 47366
- Joined: Sun Jul 04, 2010 9:50 pm
- About me: 15-32-25
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Re: Drug manufacture
Articles on the opiate crisis neglect to state the role of the DEA
https://www.npr.org/sections/health-sho ... ust-soared
The DEA is partly to blame as they have to approve the yearly amounts manufactured. They could have approved lesser amounts. Too much regulation?
https://www.npr.org/sections/health-sho ... ust-soared
The DEA is partly to blame as they have to approve the yearly amounts manufactured. They could have approved lesser amounts. Too much regulation?
https://esapolitics.blogspot.com
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late
Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late
Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...
- rainbow
- Posts: 13534
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Re: Drug manufacture
It looks like the lawyers will make lots of money and kill any incentive for innovation, but why should they care?Tero wrote: ↑Fri Jul 12, 2019 12:03 pmThis is novel: formulate an addiction treatment drug, which they invented, to make it more addictive!
https://www.npr.org/2019/07/11/74085694 ... settlement
The drug is effective if used supervised. Most European heroin addicts are on it. It is of some use in pain relief, and it does not really get you high.
https://en.m.wikipedia.org/wiki/Buprenorphine/naloxone
I call bullshit - Alfred E Einstein
BArF−4
BArF−4
- Tero
- Just saying
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Re: Drug manufacture
Companies that have public stock don't get to do this:
New York state Attorney General Letitia James says the family that owns Purdue Pharma, maker of the opioid Oxycontin, used Swiss bank accounts to transfer one billion dollars from the company to themselves.
https://www.npr.org/2019/09/13/76068888 ... -themselve
Purdue is now bankrupt
New York state Attorney General Letitia James says the family that owns Purdue Pharma, maker of the opioid Oxycontin, used Swiss bank accounts to transfer one billion dollars from the company to themselves.
https://www.npr.org/2019/09/13/76068888 ... -themselve
Purdue is now bankrupt
https://esapolitics.blogspot.com
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late
Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late
Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...
- Tero
- Just saying
- Posts: 47366
- Joined: Sun Jul 04, 2010 9:50 pm
- About me: 15-32-25
- Location: USA
- Contact:
Re: Drug manufacture
Even in the Obama era the gov't was accused of too much regulation. The DEA allowed businesses to take the risk. Poorly monitoring pharmacies.
https://esapolitics.blogspot.com
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late
Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late
Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...
- Sean Hayden
- Microagressor
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Re: Drug manufacture
Really, good. How much harder would you like to make it for people to get drugs? You already can't get a lot without providing a valid ID. There's a db being kept for every time you buy cold medicine ffs.
- Sean Hayden
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Re: Drug manufacture
I feel I should provide more relevant examples than a valid id That's just something that always bugs me.
Anyway, regulations have been proposed that include everything from requiring regular drug testing to adding patients to databases to monitor who all is taking what. Of course this data is available already, the difference would be in how it is requested, acquired, and the purpose of acquiring it.
--//--
I don't think it's a big deal to suppose that regulations vary in their usefulness across industries and according to our goals.
Anyway, regulations have been proposed that include everything from requiring regular drug testing to adding patients to databases to monitor who all is taking what. Of course this data is available already, the difference would be in how it is requested, acquired, and the purpose of acquiring it.
--//--
I don't think it's a big deal to suppose that regulations vary in their usefulness across industries and according to our goals.
- Tero
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Re: Drug manufacture
Name brand maker changes dosage (with almost the same effect, not better) to confuse generic maker and slow down validation of product.
https://www.kios.org/post/patients-stil ... te-generic
https://www.kios.org/post/patients-stil ... te-generic
https://esapolitics.blogspot.com
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late
Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late
Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...
- Svartalf
- Offensive Grail Keeper
- Posts: 40380
- Joined: Wed Feb 24, 2010 12:42 pm
- Location: Paris France
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Re: Drug manufacture
confusing generic makers, I can get, but what's the matter with validating the product? You'd think they'd want product validated fast so it can get sooner on the market.... What did I miss?
Embrace the Darkness, it needs a hug
PC stands for "Patronizing Cocksucker" Randy Ping
PC stands for "Patronizing Cocksucker" Randy Ping
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