IIRC, the ones from poppy are much more powerful than tramadol and the like.
Afghanistan. It's fucked
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Re: Afghanistan. It's fucked
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Re: Afghanistan. It's fucked
but what about the squealing of pigs?
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Re: Afghanistan. It's fucked
Thebaine can be converted into codiene, which in turn is made into codieneone.
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Re: Afghanistan. It's fucked
Not really. Fentanyl is synthetic and is much more potent and lethal. Tramadol would give you the opiate high, but it has an enantiomer that is not an opiate receptor binder. But it has other effects which give addicts the shakes at that dose.
Fentanyl binds well despite not having a phenol. Or the oxygen that both morphine and codeine have.
https://en.wikipedia.org/wiki/Fentanyl# ... e-activity
The natural opiates have to have the oxygen at the top and the one nitrogen. In fact the nitrogen is the same in all, natural and syntetic, and binds at the same spot.
https://en.wikipedia.org/wiki/Morphine
The reason there are so many semisynthetic opioids is that the receptors all have multiple functions. I think the mu receptor was favored for pain, but still gives respiratory depression. For opiate addiction treatment a mixed agonist/antagonist is sought. The "epipen" devices for overdoses have antagonist alone.
https://en.wikipedia.org/wiki/Opioid_re ... r_subtypes
Last edited by Tero on Sat Aug 28, 2021 10:39 am, edited 2 times in total.
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Re: Afghanistan. It's fucked
Yeah, no. And your names are all wrong. Morphine and codeine are the main starting materials. Morphine makes codeine so there is no sense to make it from thebaine.
https://www.incb.org/documents/Publicat ... r_II_A.pdf
the synthetic opiates in the chart are all derived from naturals except maybe methadone.
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Re: Afghanistan. It's fucked
Antagonists:
The "epipen" devices for overdoses have antagonist alone. Naloxone. It is made from morphine.
https://en.wikipedia.org/wiki/Naloxone
The "epipen" devices for overdoses have antagonist alone. Naloxone. It is made from morphine.
https://en.wikipedia.org/wiki/Naloxone
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Re: Afghanistan. It's fucked
I bet the reducing number of service personnel at Kabul airport are getting very itchy to be out of there. I can't see how it can be managed without leave bodies on the ground. Even if the US negotiate a ceasefire with the Taliban at some point there's not going to be enough troops to defend the perimeter and there's thousands of people at the fence. ISIS will have no truck with a Taliban-US ceasefire. Are we going to see the USAF strafing civilians to get the last of the forces on the ground out? Are the US going to destroy/sabotage the kit they're going to have to leave behind, perhaps rendering the airport useless? There's already a massive humanitarian crisis in the country. It has no functional government at the moment. The banks are closed. Food supplies and distribution are in turmoil. Water is in short supply. It already relies on NGOs and overseas donations for medical supplies and healthcare. What's going to happen to that when the West is out of there?
BBC wrote:The Red Cross in Afghanistan: 'If we leave, who stays?'
As thousands of people head to borders and Kabul airport to flee Afghanistan, some on the ground say they have no choice but to stay.
Dr Alberto Cairo is head of the Kabul orthopaedic project, part of the International Committee of the Red Cross' operations in Kabul, and has worked in Afghanistan since 1990.
He said that he hopes people do not forget about Afghanistan and that the country needs support from the international community.
Dr Cairo's comments come after the UK confirmed it was in the final stages of its evacuation process...
(+video) https://www.bbc.co.uk/newsround/58344607
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Clinton Huxley » 21 Jun 2012 » 14:10:36 GMT
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Clinton Huxley » 21 Jun 2012 » 14:10:36 GMT
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Re: Afghanistan. It's fucked
From your linky-poo:Tero wrote: ↑Sat Aug 28, 2021 10:13 amYeah, no. And your names are all wrong. Morphine and codeine are the main starting materials. Morphine makes codeine so there is no sense to make it from thebaine.
https://www.incb.org/documents/Publicat ... r_II_A.pdf
BTW: oxycodone = dihydrohydroxycodeinoneGlobal manufacture of thebaine has increased
sharply since the late 1990s, as a consequence of the grow-
ing demand for oxycodone and other drugs and substances
that may be derived from it (see figure 2).
I call bullshit - Alfred E Einstein
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Re: Afghanistan. It's fucked
That's a great Scrabble score.
Rationalia relies on voluntary donations. There is no obligation of course, but if you value this place and want to see it continue please consider making a small donation towards the forum's running costs.
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There are two other possibilities: one is paperwork, and the other is nostalgia."
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Clinton Huxley » 21 Jun 2012 » 14:10:36 GMT
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Details on how to do that can be found here.
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"It isn't necessary to imagine the world ending in fire or ice.
There are two other possibilities: one is paperwork, and the other is nostalgia."
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Clinton Huxley » 21 Jun 2012 » 14:10:36 GMT
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Re: Afghanistan. It's fucked
Woodbutcher wrote: ↑Sat Aug 28, 2021 1:03 amI'd like to see that! Reduce the world population to about 500 million, the clouds would bring about global cooling, and fishing and hunting would improve.![]()
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Yeah well that's just, like, your opinion, man.
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Re: Afghanistan. It's fucked
Tramadol? I don't know, but when I broke my wrist, it hurt so bad I popped them like candy, and I never got a high, or for that matter any cold turkey effects when I stopped it once it stopped hurting.Tero wrote: ↑Sat Aug 28, 2021 10:10 amNot really. Fentanyl is synthetic and is much more potent and lethal. Tramadol would give you the opiate high, but it has an enantiomer that is not an opiate receptor binder. But it has other effects which give addicts the shakes at that dose.
Fentanyl binds well despite not having a phenol. Or the oxygen that both morphine and codeine have.
https://en.wikipedia.org/wiki/Fentanyl# ... e-activity
The natural opiates have to have the oxygen at the top and the one nitrogen. In fact the nitrogen is the same in all, natural and syntetic, and binds at the same spot.
https://en.wikipedia.org/wiki/Morphine
The reason there are so many semisynthetic opioids is that the receptors all have multiple functions. I think the mu receptor was favored for pain, but still gives respiratory depression. For opiate addiction treatment a mixed agonist/antagonist is sought. The "epipen" devices for overdoses have antagonist alone.
https://en.wikipedia.org/wiki/Opioid_re ... r_subtypes
Embrace the Darkness, it needs a hug
PC stands for "Patronizing Cocksucker" Randy Ping
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Re: Afghanistan. It's fucked
Alll who dislike islamists leave, the morons stayBrian Peacock wrote: ↑Sat Aug 28, 2021 11:04 amI bet the reducing number of service personnel at Kabul airport are getting very itchy to be out of there. I can't see how it can be managed without leave bodies on the ground. Even if the US negotiate a ceasefire with the Taliban at some point there's not going to be enough troops to defend the perimeter and there's thousands of people at the fence. ISIS will have no truck with a Taliban-US ceasefire. Are we going to see the USAF strafing civilians to get the last of the forces on the ground out? Are the US going to destroy/sabotage the kit they're going to have to leave behind, perhaps rendering the airport useless? There's already a massive humanitarian crisis in the country. It has no functional government at the moment. The banks are closed. Food supplies and distribution are in turmoil. Water is in short supply. It already relies on NGOs and overseas donations for medical supplies and healthcare. What's going to happen to that when the West is out of there?
BBC wrote:The Red Cross in Afghanistan: 'If we leave, who stays?'
As thousands of people head to borders and Kabul airport to flee Afghanistan, some on the ground say they have no choice but to stay.
Dr Alberto Cairo is head of the Kabul orthopaedic project, part of the International Committee of the Red Cross' operations in Kabul, and has worked in Afghanistan since 1990.
He said that he hopes people do not forget about Afghanistan and that the country needs support from the international community.
Dr Cairo's comments come after the UK confirmed it was in the final stages of its evacuation process...
(+video) https://www.bbc.co.uk/newsround/58344607
Embrace the Darkness, it needs a hug
PC stands for "Patronizing Cocksucker" Randy Ping
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Re: Afghanistan. It's fucked
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Re: Afghanistan. It's fucked
It's only the single high dose that gave the other effects.
Tramadol has been found to possess these actions:...some of them from opiate receptor inactive isomer.
Agonist of the μ-opioid receptor (MOR) and to a far lesser extent of the δ-opioid receptor (DOR) and κ-opioid receptor (KOR)
Serotonin reuptake inhibitor (SRI) and norepinephrine reuptake inhibitor; hence, an SNRI
Serotonin 5-HT2C receptor antagonist
M1 and M3 muscarinic acetylcholine receptor antagonist
α7 nicotinic acetylcholine receptor antagonist
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